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 6-溴雄烯酮 38632-00-7
6-溴雄烯酮
 產(chǎn)品別名: 6-溴-3,17-二氧雄烷, 6-溴雄烯酮，6-溴雄烷，
產(chǎn)品含量: 97%  
質(zhì)量標(biāo)準(zhǔn): 企業(yè)標(biāo)準(zhǔn)  
產(chǎn)品含量: 97% 
包裝規(guī)格: 1kg 
分子量: c19h26 br o2=366.41 
理化性質(zhì):白色固體,見(jiàn)光,受熱易分解變色,宜冷凍避光貯存.熔點(diǎn):100-102℃. 
制備方法:由4-雄烯二酮與溴素反應(yīng)制備.
用途:本品是一種醫(yī)藥中間體.


（6-溴雄烯酮）
Product Name：6-Bromoandrostenedione
CAS Number：38632-00-7
A selective inhibitor of aromatase (estrogen synthetase) would be a useful pharmacological tool with potential therapeutic application. We have found that 6 alpha-bromoandrostenedione (6 alpha-BrA) is a competitive inhibitor of human ntal aromatase with respect to androstenedione, with an apparent Ki of 3.4 nM, while 6 beta-BrA is a mechanism-based irreversible inhibitor with an apparent Ki of 0.8 microM and a kinact of 0.025 min-1. Aromatase activity was measured by tritium release into water from the 1 beta position of [1(-3)H,4(-14)C]androstenedione in reaction mixtures containing NADPH and the aromatase.